反应详情

温度

80 °C

A mixture of approximately equimolar quantities of ethyl valerimidate carbethoxyhydrazone (from Step A) and methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate (Step F) in ethanol is stirred at 80° C. under N2. After about 2 hours, or when TLC indicates complete reaction, the mixture is cooled and concentrated to dryness. The residue is re-concentrated from CH2Cl2 and then chromatographed on silica gel to yield the title compound.

1. customreaction
2. temperaturethe mixture is cooled
3. concentrationconcentrated to dryness
4. concentrationThe residue is re-concentrated from CH2Cl2
5. customchromatographed on silica gel