HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 257846Generated: October 31, 2026
Methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate → 5-butyl-4-[4-[(1-carbomethoxy)(1-(2-chlorophenyl))methoxy]phenyl]methyl-2,4-dihydro-3H-1,2,4-triazol-3-one
https://huagongshe.com/reaction/257846
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate | HCID 19781920 | — |
| Reactant | Ethyl valerate carbethoxyhydrazone | HCID 53752329 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-butyl-4-[4-[(1-carbomethoxy)(1-(2-chlorophenyl))methoxy]phenyl]methyl-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 19781890 | — |
Reaction Steps
A mixture of approximately equimolar quantities of ethyl valerimidate carbethoxyhydrazone (from Step A) and methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate (Step F) in ethanol is stirred at 80° C. under N2. After about 2 hours, or when TLC indicates complete reaction, the mixture is cooled and concentrated to dryness. The residue is re-concentrated from CH2Cl2 and then chromatographed on silica gel to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05264439 |
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| Source dataset | uspto-grants-1993_11 |
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| ORD ID | ord-5d3831f9bee3421ca572860631ca2b71 |
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| Source note | uspto-grants-1993_11 |
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