Methyl iodide → HCID 19075336, compound

HRID 257883Notes

Reaction equation

HRID 257883 reaction equation
[CH3:1][I:2].[CH2:3]([O:6][C:7]1[C:8]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[N:9][S:10][N:11]=1)[C:4]#[CH:5]>CC(C)=O>[I-:2].[CH2:3]([O:6][C:7]1[C:8]([C:12]2[CH:13]=[N+:14]([CH3:1])[CH:15]=[CH:16][CH:17]=2)=[N:9][S:10][N:11]=1)[C:4]#[CH:5]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19075253HCID 19075253, compound

Product 1

HCID 19075336HCID 19075336, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.45 ml, 7.2 mmol) and 3-(4-propargyloxy-1,2,5-thiadiazol-3-yl)pyridine (430 mg, 2.4 mmol) in acetone (5 ml) was stirred at room temperature for 18 h. The title compound precipitated from the solution and was collected by filtration to yield 0.58 g (67%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration
  3. customto yield 0.58 g (67%)

Sources & evidence

ORD record
ord-98dc995d3dd748c497230d02eb1f51c7
Source dataset
uspto-grants-1993_11
Patent number
US05264444

Reaction notes

Loading…