Methyl iodide → 3-(3-Amino-1,2,5-oxadiazol-4-yl)-1-methylpyridinium iodide

HRID 257943Notes

Reaction equation

HRID 257943 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][O:5][N:6]=1.[CH3:13][I:14]>CC(C)=O>[I-:14].[NH2:1][C:2]1[C:3]([C:7]2[CH:8]=[N+:9]([CH3:13])[CH:10]=[CH:11][CH:12]=2)=[N:4][O:5][N:6]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 14155234-Pyridin-3-yl-1,2,5-oxadiazol-3-amine

Product 1

HCID 190753223-(3-Amino-1,2,5-oxadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 3-(4-amino-1,2,5-oxadiazol-3-yl)pyridine (870 mg, 5.3 mmol) in acetone (20 ml) was added methyl iodide (990 μl , 16 mmol) and the reaction mixture was stirred overnight at room temperature. The title compound precipitated and was collected by filtration (1.1 g, 69%).

Workup

  1. customThe title compound precipitated
  2. filtrationwas collected by filtration (1.1 g, 69%)

Sources & evidence

ORD record
ord-e3c36da1faa84b0c80ac9aadfa4d4ba8
Source dataset
uspto-grants-1993_11
Patent number
US05264444

Reaction notes

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