Trifluoroacetic acid → HCID 67656846, compound

Participants

Reaction Steps

To an ice-cooled stirred solution of benzhydryl 7α-bromo-2-methylene-3-methyl-3-cephem-4-carboxylate-1, 1-dioxide (from step D, Example 2, 1.0 g, 2.047 mmol) in dry anisole (10 ml) was added trifluoroacetic acid (4.0 ml) and the mixture was stirred at ice-temperature for 1 hour; solvent was removed under reduced pressure to leave a yellow oil. Hexane was added directly to the yellow oil while a white solid was precipitated out which was collected by filtration (0.549 g, 83%).

Provenance & Evidence