Trifluoroacetic acid → HCID 67656846, compound

HRID 258005Notes

Reaction equation

HRID 258005 reaction equation
[Br:1][C@H:2]1[C:29](=[O:30])[N:4]2[C:5]([C:13]([O:15]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:14])=[C:6]([CH3:12])[C:7](=[CH2:11])[S:8](=[O:10])(=[O:9])[C@H:3]12.FC(F)(F)C(O)=O.CCCCCC>C1(OC)C=CC=CC=1>[Br:1][C@H:2]1[C:29](=[O:30])[N:4]2[C:5]([C:13]([OH:15])=[O:14])=[C:6]([CH3:12])[C:7](=[CH2:11])[S:8](=[O:10])(=[O:9])[C@H:3]12

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 8058HexaneHCID 15280796HCID 15280796, compound

Product 1

HCID 67656846HCID 67656846, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

To an ice-cooled stirred solution of benzhydryl 7α-bromo-2-methylene-3-methyl-3-cephem-4-carboxylate-1, 1-dioxide (from step D, Example 2, 1.0 g, 2.047 mmol) in dry anisole (10 ml) was added trifluoroacetic acid (4.0 ml) and the mixture was stirred at ice-temperature for 1 hour; solvent was removed under reduced pressure to leave a yellow oil. Hexane was added directly to the yellow oil while a white solid was precipitated out which was collected by filtration (0.549 g, 83%).

Workup

  1. customsolvent was removed under reduced pressure
  2. customto leave a yellow oil
  3. customwas precipitated out which
  4. filtrationwas collected by filtration (0.549 g, 83%)

Sources & evidence

ORD record
ord-e7c321b1c62845ccbe4fcad006ff8663
Source dataset
uspto-grants-1993_11
Patent number
US05264429

Reaction notes

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