Isopropanol → Propham

HRID 258066Notes

Reaction equation

[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:10]([OH:13])([CH3:12])[CH3:11]>>[C:1]1([NH:7][C:8](=[O:9])[O:13][CH:10]([CH3:12])[CH3:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 3776Isopropanol

HCID 7672Phenyl isocyanate

Product 1

HCID 24685ProphamYield 16.1%

Procedure

A liquid mixture of 50 g (0.42 mol) of phenyl isocyanate and 6.43 ml (0.084 mol) of isopropanol was stirred at room temperature for 20 minutes and thereafter an unreacted raw material was distilled away under a reduced pressure to obtain 16.1% of isopropyl N-phenylcarbamate.

Workup

distillationan unreacted raw material was distilled away under a reduced pressure

Sources & evidence

ORD record: ord-f59c654b12d643fd941585620047729c
Source dataset: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05264572

Reaction notes

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