Hydrochloric Acid → 2-Chlorohypoxanthine

HRID 258074Notes

Reaction equation

HRID 258074 reaction equation
O.[Cl:2][C:3]1[NH:4][C:5](=[O:12])[C:6]2[NH:7][CH:8]=[N:9][C:10]=2[N:11]=1.[Na].Cl>O>[Cl:2][C:3]1[NH:4][C:5](=[O:12])[C:6]2[NH:7][CH:8]=[N:9][C:10]=2[N:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136331507Sodium 2-chlorohypoxanthine hydrate

Product 1

HCID 1354217922-Chlorohypoxanthine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

20 g of sodium 2-chlorohypoxanthine-hydrate are suspended in 400 ml of water, the pH is adjusted to 6.5 in the reaction solution using dilute hydrochloric acid and the mixture is heated to about 60° C. After treatment with 2 g of decolorising charcoal and filtration, the 2-chlorohypoxanthine is precipitated and isolated in the same way as described in Example 2 (at pH 3.0 +/- 0.5 and at ambient temperature). 11.6 g (8% of theory) of the title compound are obtained in the form of colourless crystals. According to HPLC analysis the product has a degree of purity of more than 99%.

Workup

  1. filtrationAfter treatment with 2 g of decolorising charcoal and filtration
  2. customthe 2-chlorohypoxanthine is precipitated
  3. customisolated in the same way
  4. customas described in Example 2 (at pH 3.0 +/- 0.5 and at ambient temperature)

Sources & evidence

ORD record
ord-30a34e3090e34cb7a3d2a115502280f0
Source dataset
uspto-grants-1993_11
Patent number
US05264573

Reaction notes

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