Glycine → HCID 19737117, compound

HRID 258222Notes

Reaction equation

HRID 258222 reaction equation
NC[C:3](O)=[O:4].[NH2:6][CH:7]([CH:11]([OH:16])[CH2:12][CH2:13][CH2:14][OH:15])[C:8]([OH:10])=[O:9]>>[NH2:6][CH:7]([CH:11]([OH:16])[CH2:12][CH2:13][CH2:14][O:15][CH:3]=[O:4])[C:8]([OH:10])=[O:9]

Participants

3

Reactant 2

HCID 750Glycine2×HCID 19737116HCID 19737116, compound

Product 1

HCID 19737117HCID 19737117, compound

Procedure

From the first aliquot taken at 0.5 h, two new amino aids were noted upon amino acid analysis. A small peak appeared at 15.6 min, just after the glycine peak. The other was a large, sharp peak at 22.5 minutes. By three hours, the peak at 22.5 minutes, corresponding to the expected amino acid reached a maximum at about 10% of the glycine peak and then slowly decreased while the peak at 15.6 minutes increased slightly in intensity. The amino acid eluting at 15.6 min is the product from slow hydrolysis of the formate ester in the reaction medium. The structure corresponds to α-amino-β-hydroxy-6-hydroxyhexanoic acid.

Workup

  1. waitA small peak appeared at 15.6 min
  2. customat 22.5 minutes
  3. waitBy three hours
  4. waitthe peak at 22.5 minutes
  5. waitslowly decreased while the peak at 15.6 minutes
  6. temperatureincreased slightly in intensity

Sources & evidence

ORD record
ord-c23daba857c141e0ba983764e8c43005
Source dataset
uspto-grants-1993_11
Patent number
US05266468

Reaction notes

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