HCID 19737208, compound → HCID 19737189, compound

HRID 258260Notes

Reaction equation

HRID 258260 reaction equation
[Cl:1][C:2]1[C:3]([N:12]2[C:20]3[C:15](=[CH:16][C:17]([N+:24]([O-])=O)=[C:18]([N+:21]([O-])=O)[CH:19]=3)[CH:14]=[N:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[C:3]([N:12]2[C:20]3[C:15](=[CH:16][C:17]([NH2:24])=[C:18]([NH2:21])[CH:19]=3)[CH:14]=[N:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 1

HCID 19737208HCID 19737208, compound

Product 1

HCID 19737189HCID 19737189, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

1-(3-Chloro-5-trifluoromethylpyridin-2-yl) -5,6-dinitroindazole [Compound No. 28] (8.0 g) was dissolved in ethyl acetate (100 g) and reduced with 10% Pd-C (0.1 g) at ordinary temperature under atmospheric pressure for 8 hours. After completion of the reaction, the reaction mixture was filtered to remove the Pd-C, and the filtrate was concentrated under reduced pressure to give 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-5,6-diaminoindazole (7.2 g).

Workup

  1. customAfter completion of the reaction
  2. filtrationthe reaction mixture was filtered
  3. customto remove the Pd-C
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ed2effe68e984ef7b83c7bff62ce4f80
Source dataset
uspto-grants-1993_11
Patent number
US05266556

Reaction notes

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