Glycine → HCID 19781177, compound

Participants

Reaction Steps

By the method of M. Shimazaki, et al., Chem. Pharm. Bull., 30(9), 3139-3146 (1982), 2.27 g glycine in a solution of 31 mL of 2 M sodium hydroxide was stirred with commercially available chloropivaloyl chloride (4.65 g) in 5 mL ether. After one hour at 0° C., the reaction mixture was warmed to ambient temperature, acidified (pH 2) with sulfuric acid and saturated with sodium chloride. After extraction with 3×30 mL ethyl acetate, the extracts were dried (MgSO4) and evaporated in vacuo to give 3.0 g of the title compound as a white solid. This material was used as obtained in the following transformation.

Provenance & Evidence