反应详情

The aldehyde of Step 1 (46.64 g, 156.6 mmol) was dissolved in 300 mL of THF. At 0° C., 800 mL of EtOH was added, followed by NaBH4 (5.93 g, 157 mmol). The mixture was then stirred at r.t. (room temperature) for 1 h and poured into cold 25% aq (aqueous) NH4OAc. The organic solvents were evaporated and the title alcohol was extracted with toluene:THF 1:1, dried over Na2SO4 and filtered through silica to yield 47.9 g of the title compound.

1. customThe organic solvents were evaporated
2. extractionthe title alcohol was extracted with toluene:THF 1:1
3. dry with materialdried over Na2SO4
4. filtrationfiltered through silica