Ethyl 2-(mercaptomethyl)butanoate → Ethyl 3-((1-(3-((7-chloro-2-quinolinyl)methoxy)phenyl)-3-(2-(2-hydroxy-2-propyl)phenyl)propyl)thio)-2-ethylpropanoate

HRID 258486Notes

Reaction equation

HRID 258486 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH:20](O)[CH2:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([CH3:32])([CH3:31])[OH:30])[CH:17]=[CH:18][CH:19]=3)=[N:9]2)=[CH:4][CH:3]=1.[SH:34][CH2:35][CH:36]([CH2:42][CH3:43])[C:37]([O:39][CH2:40][CH3:41])=[O:38]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH:20]([S:34][CH2:35][CH:36]([CH2:42][CH3:43])[C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH2:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([OH:30])([CH3:32])[CH3:31])[CH:17]=[CH:18][CH:19]=3)=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 19737259Ethyl 2-(mercaptomethyl)butanoateHCID 197372702-(3-(3-((7-Chloro-2-quinolinyl)methoxy)phenyl)-3-hydroxypropyl)-alpha,alpha-dimethylbenzenemethanol

Product 1

HCID 53942369Ethyl 3-((1-(3-((7-chloro-2-quinolinyl)methoxy)phenyl)-3-(2-(2-hydroxy-2-propyl)phenyl)propyl)thio)-2-ethylpropanoateYield 64%

Procedure

Starting from the diol of Example 5, Step 1, and using the procedure of Example 1, Method B, Step 7, but substituting the thiol of Step 2 for ethyl 2-(mercaptomethyl)butanoate, the title compound was prepared. Yield: 64%.

Sources & evidence

ORD record
ord-389412f4dfb543b3b73f4e43b43e0e2d
Source dataset
uspto-grants-1993_11
Patent number
US05266568

Reaction notes

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