Hydrochloric Acid → 4-Chloro-2-fluoroaniline

HRID 258493Notes

Reaction equation

HRID 258493 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([NH:6]C(=O)C)=[C:4]([F:12])[CH:3]=1.Cl>C(O)C>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([NH2:6])=[C:4]([F:12])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 8531744'-Chloro-2'-fluoroacetanilide

Product 1

HCID 938984-Chloro-2-fluoroaniline

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 119 parts of 4'-chloro-2'-fluoroacetanilide in 475 parts of ethanol and 200 parts of 37% hydrochloric acid was refluxed for 17 hours and the solvent was removed under reduced pressure of 300 mm Hg to yield the moist, solid hydrochloride salt of 4-chloro-2-fluoroaniline.

Workup

  1. temperaturewas refluxed for 17 hours
  2. customthe solvent was removed under reduced pressure of 300 mm Hg

Sources & evidence

ORD record
ord-cb2af283966745bd86d09e91d65cd7b4
Source dataset
uspto-grants-1977_07
Patent number
US04033751

Reaction notes

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