Phosphorus sulfide (P2S5) → 7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione

HRID 258539Notes

Reaction equation

HRID 258539 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[NH:6][C:7](=O)[CH2:8][C:9](=[O:17])[N:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:22]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[NH:6][C:7](=[S:22])[CH2:8][C:9](=[O:17])[N:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 89657Desmethylclobazam

Product 1

HCID 122643197-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 28.6 g of 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione and 23.3 g of phosphorus pentasulfide in 250 ml of pyridine is refluxed, with stirring, for 40 minutes under argon. The solvent is evaporated in vacuo.

Workup

  1. customThe solvent is evaporated in vacuo

Sources & evidence

ORD record
ord-16e1f113ba5a45a996d8f2187a1699d1
Source dataset
uspto-grants-1977_07
Patent number
US04033947

Reaction notes

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