HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus sulfide (P2S5) → 7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | Desmethylclobazam | HCID 89657 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione | HCID 12264319 | — |
Reaction Steps
A solution of 28.6 g of 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione and 23.3 g of phosphorus pentasulfide in 250 ml of pyridine is refluxed, with stirring, for 40 minutes under argon. The solvent is evaporated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04033947 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-16e1f113ba5a45a996d8f2187a1699d1 |
| Source note | uspto-grants-1977_07 |