Ammonia → HCID 20365142, compound

HRID 258574Notes

Reaction equation

HRID 258574 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH:4]([CH2:7][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])O)[CH2:3]1.N.[Li]>>[CH3:16][C:11]1[CH2:12][CH:13]=[CH:14][CH2:15][C:10]=1[CH2:8][CH2:7][CH:4]1[CH2:5][CH2:6][N:2]([CH3:1])[CH2:3]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 3028194LithiumHCID 20365138HCID 20365138, compound

Product 1

HCID 20365142HCID 20365142, compound

Procedure

A sample of 1-methyl-α-(2-methylphenyl)-3-pyrrolidine-ethanol (23 α, 0.105 moles) is subjected to Birch reduction in 500 ml liquid ammonia with 7 g (1 mole) of lithium to give a quantitative yield of 3-(3,6-dihydro-2-methylphenethyl)-N-methylpyrrolidine.

Sources & evidence

ORD record
ord-c70862bbdeb14932b279b5d1b922d579
Source dataset
uspto-grants-1977_07
Patent number
US04033971

Reaction notes

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