HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetoxy-1-(3-bromo-1-propynyl)cyclooctane → 7-{N-[3(1-hydroxycyclooctyl)propyl]methanesulfonamido}heptanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetoxy-1-(3-bromo-1-propynyl)cyclooctane | HCID 20322240 | — |
| Reactant | Ethyl 7-{[3-(1-acetoxycyclooctyl)-2-propynyl]methanesulfonamido}heptanoate | HCID 20327721 | — |
| Reactant | 1-bromo-4(R)-acetoxy-2-nonyne | HCID 22793816 | — |
| Product | 7-{N-[3(1-hydroxycyclooctyl)propyl]methanesulfonamido}heptanoic acid | HCID 20327691 | — |
| Product | ethyl 7-[N-(4-acetoxy-(E)-2-nonenyl)methanesulfonamido]heptanoic acid | HCID 20327696 | — |
Reaction Steps
The synthesis of this compound is carried out as described in Example 3, except that, in Step A, the 1-bromo-4(R)-acetoxy-2-nonyne is replaced by an equimolar amount of 1-acetoxy-1-(3-bromo-1-propynyl)cyclooctane (Example V). The product of Step A is thus ethyl 7-{[3-(1-acetoxycyclooctyl)-2-propynyl]methanesulfonamido}heptanoate. The subsequent steps yield 7-{N-[3-(1-hydroxycyclooctyl)-2-propynyl]methanesulfonamido}heptanoic acid (B) and 7-{N-[3(1-hydroxycyclooctyl)propyl]methanesulfonamido}heptanoic acid (C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04033996 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-f76e47127b6f4d47b89046b4103d4898 |
| Source note | uspto-grants-1977_07 |