1-Bromo-4-acetoxy-4-propyl-2-heptyne → 7-{N-[3(1-hydroxycyclooctyl)propyl]methanesulfonamido}heptanoic acid

Participants

Reaction Steps

The synthesis of this compound is carried out as described in Example 3, except that, in Step A, the 1-bromo-4(R)-acetoxy-2-nonyne is replaced by an equimolar amount of 1-bromo-4-acetoxy-4-propyl-2-heptyne (Example W). The product of Step A is thus ethyl 7-[N-(4-acetoxy-4-propyl-2-heptynyl)methanesulfonamido]heptanoate. The subsequent steps yield 7-[N-(4-hydroxy-4-propyl-2-heptynyl)methanesulfonamido]heptanoic acid (B) and 7-[N-(4-hydroxy-4-propyhexyl)methanesulfonamido]heptanoic acid (C).

Provenance & Evidence