反应详情

4-Methoxyquinaldic acid (7.25 g) was dissolved in dry dimethylformamide (20 ml). N,N'-carbonyldiimidazole (5.8 g) was added, and the solution was stirred for 6 hours at room temperature. 5-Aminotetrazole (3.69 g) was added and the mixture was stirred overnight at room temperature. The solid was filtered off, washed with methanol and dissolved in dimethylformamide (50 ml) with the minimum addition of dimethylaminoethanol to effect dissolution. Water (50 ml) was added, and the solution was adjusted to pH 2 by the addition of aqueous hydrochloric acid. The solid was filtered off to give 4-methoxy-N(1H-tetrazol- 5-yl)quinaldamide, m.p. 289° (d).

1. stirringthe mixture was stirred overnight at room temperature
2. filtrationThe solid was filtered off
3. washwashed with methanol
4. dissolutiondissolved in dimethylformamide (50 ml) with the minimum addition of dimethylaminoethanol
5. dissolutiondissolution
6. additionWater (50 ml) was added
7. additionthe solution was adjusted to pH 2 by the addition of aqueous hydrochloric acid
8. filtrationThe solid was filtered off