HCID 21426392, compound → HCID 178450204, compound

HRID 258677Notes

Reaction equation

HRID 258677 reaction equation
[CH2:1]([O:5][C:6]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[C:8]([C:9](O)=[O:10])[CH:7]=1)[CH2:2][CH2:3][CH3:4].[NH2:19][C:20]1[NH:24][N:23]=[N:22][N:21]=1>CN(C)C=O>[CH2:1]([O:5][C:6]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[C:8]([C:9]([NH:19][C:20]2[NH:24][N:23]=[N:22][N:21]=2)=[O:10])[CH:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 21426392HCID 21426392, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178450204HCID 178450204, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Butyloxyquinaldic acid (0.83 g) in dry dimethylformamide (25 ml) was treated with N,N'-carbonyldiimidazole (0.55 g) and the mixture stirred at 60° for 3 hours. 5-Aminotetrazole (0.35 g) was added and the solution kept 72 hours and evaporated to a volume of 5 ml. Dilute hydrochloric acid was added and the 4-butyloxy-N(1H-tetrazol-5-yl)quinaldamide formed was crystallised from aqueous dimethylformamide, m.p. 282° (d).

Workup

  1. waitthe solution kept 72 hours
  2. customevaporated to a volume of 5 ml
  3. additionDilute hydrochloric acid was added

Sources & evidence

ORD record
ord-dd7408656e9d4ecea86b8a4006a20f8f
Source dataset
uspto-grants-1977_07
Patent number
US04034075

Reaction notes

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