Ammonia → HCID 178513877, compound

HRID 258686Notes

Reaction equation

HRID 258686 reaction equation
[C:1]([CH2:6][C:7]1[O:8][C:9]([SH:12])=[N:10][N:11]=1)(OCC)=[O:2].[NH3:13]>C(O)C>[C:1]([CH2:6][C:7]1[O:8][C:9]([SH:12])=[N:10][N:11]=1)(=[O:2])[NH2:13]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 1784707932-Carbethoxymethyl-1,3,4-oxadiazol-5-thiol

Product 1

HCID 178513877HCID 178513877, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 1.88 g (0.01 mol) of 2-carbethoxymethyl-1,3,4-oxadiazol-5-thiol in 25 ml of absolute ethanol is added dropwise at ambient temperature to 100 ml of a saturated solution of anhydrous ammonia in absolute ethanol. When the reaction is complete, as evidenced by thin layer chromatography, the solution is evaporated to dryness. The residue is dissolved in 100 ml of water and the aqueous solution is acidified to pH 2.5 with dilute hydrochloric acid and extracted with ethyl acetate. The extract is dried (MgSO4) and evaporated to dryness to give 2-carbamoylmethyl-1,3,4-oxadiazole-5-thiol.

Workup

  1. customthe solution is evaporated to dryness
  2. dissolutionThe residue is dissolved in 100 ml of water
  3. extractionextracted with ethyl acetate
  4. dry with materialThe extract is dried (MgSO4)
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-3246d91f8935431ebe5ced0f8cf2aa46
Source dataset
uspto-grants-1977_07
Patent number
US04034092

Reaction notes

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