反应详情

Treatment of 2.93 g (10 mmole) of ethyl 1-(4-chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine-5-carboxylate prepared as in Example 1 with either 20 ml of concentrated hydrochloric acid or a mixture of 10 ml of concentrated hydrochloric acid and 10 ml of acetic acid at reflux for 5 hours gives, after methylene chloride extraction and ethanol recrystallization, a 40-45% yield of 1-(4-chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine, m.p. 177°-9° C.

1. temperatureat reflux for 5 hours
2. customgives
3. extractionafter methylene chloride extraction and ethanol recrystallization