反应详情

Ethyl (2-mesyl-imidazol-1-yl)-acetate (21.4 g.) in 4N sulphuric acid (50 cc.) is heated under reflux for 11/2 hours. A product crystallises on cooling. Crystallisation is completed by keeping the mixture in a bath of ice and water for 5 hours. After filtration, crystals (13.7 g.) which melt at 216- 217° C. are obtained. Recrystallisation from water (110 cc.) gives (2-mesylimidazol-1-yl)-acetic acid (12.7 g.), melting at 218- 219° C.

1. temperatureunder reflux for 11/2 hours
2. customA product crystallises
3. temperatureon cooling
4. customCrystallisation
5. customfor 5 hours
6. filtrationAfter filtration, crystals (13.7 g.) which melt at 216- 217° C.
7. customare obtained
8. customRecrystallisation from water (110 cc.)