Ammonia → HCID 70633743, compound

HRID 258708Notes

Reaction equation

HRID 258708 reaction equation
[ClH:1].[CH2:2]([CH:9]1[CH:14]([CH2:15][C:16]([OH:18])=[O:17])[CH2:13][CH2:12][NH:11][CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.N.[CH2:20]=O.Cl>C(O)=O>[ClH:1].[CH2:2]([CH:9]1[CH:14]([CH2:15][C:16]([OH:18])=[O:17])[CH2:13][CH2:12][N:11]([CH3:20])[CH2:10]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 70634190HCID 70634190, compound

Product 1

HCID 70633743HCID 70633743, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of 95 g of 3-benzyl-4-piperidine-acetic acid hydrochloride (isomeric mixture), 30 ml of concentrated ammonia solution, 900 ml of 33% formaldehyde solution and 140 ml of 90% formic acid is heated for 18 hours at boiling temperature. After cooling to room temperature and adding 120 ml of concentrated hydrochloric acid, the mixture is evaporated to dryness under reduced pressure and the residue is dried under high vacuum for 5 hours at 100°. The crude 3-benzyl-1-methyl-4-piperidine-acetic acid hydrochloride (isomeric mixture) obtained is further reacted without purification.

Workup

  1. temperatureis heated for 18 hours
  2. customthe mixture is evaporated to dryness under reduced pressure
  3. customthe residue is dried under high vacuum for 5 hours at 100°

Sources & evidence

ORD record
ord-c4c61660ec1549fd83b75075b20d5a12
Source dataset
uspto-grants-1977_07
Patent number
US04034095

Reaction notes

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