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HRID 258745作成日：2026年10月25日
Hydrochloric Acid → N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride
https://huagongshe.com/reaction/258745
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Bicarbonate | HCID 516893 | — |
| 反応物 | N-methyl-N-tert-butoxycarbonylhydrazine sulphate | HCID 88794812 | — |
| 反応物 | HCID 178485010 | HCID 178485010 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride | HCID 178486240 | — |
反応手順
A mixture of the isothiourea dihydrochloride of Example 1 (i) (6.7 g), N-methyl-N-tert-butoxycarbonylhydrazine sulphate (5.7 g), potassium hydrogen carbonate (10.0 g) and anhydrous dimethylformamide (80 ml) was stirred at 90° C. for 3 hours. After cooling, filtration and concentration to yield the free base, this was heated under reflux with ethanolic hydrogen chloride. Concentration and trituration of the residual product yielded the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04034101 |
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| 出典データセット | uspto-grants-1977_07 |
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| ORD ID | ord-ae33860c3be94f0fa9214fab10a9ef6e |
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| 出典メモ | uspto-grants-1977_07 |
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