反应详情

温度

90 °C

A mixture of the isothiourea dihydrochloride of Example 1 (i) (6.7 g), N-methyl-N-tert-butoxycarbonylhydrazine sulphate (5.7 g), potassium hydrogen carbonate (10.0 g) and anhydrous dimethylformamide (80 ml) was stirred at 90° C. for 3 hours. After cooling, filtration and concentration to yield the free base, this was heated under reflux with ethanolic hydrogen chloride. Concentration and trituration of the residual product yielded the title compound.

1. temperatureAfter cooling
2. filtrationfiltration and concentration
3. customto yield the free base
4. temperaturethis was heated
5. concentrationConcentration and trituration of the residual product