Dimethyl 3-oxoglutarate → Methyl 3-[7-(diethylamino)-2-oxo-2h-chromen-3-yl]-3-oxopropanoate

Participants

Reaction Steps

A solution of 1.93 g 4-diethylaminosalicylaldehyde, 1.80 g. dimethyl 1,3-acetone dicarboxylate in 10 ml. alcohol containing 10 drops piperidine was heated under reflux on a steam bath for 2 hours. After chilling in the freezer, the product was collected and recrystallized from a mixture of alcohol and acetonitrile. Yield 2.6 g (82%).

Provenance & Evidence