Thioacetamide → HCID 12369471, compound

HRID 258866Notes

Reaction equation

HRID 258866 reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]#[N:11].C(N)(=[S:14])C>>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10](=[S:14])[NH2:11]

Participants

3

Reactant 2

HCID 2723949ThioacetamideHCID 117448131-Methyl-5-nitro-1H-imidazole-2-carbonitrile

Product 1

HCID 12369471HCID 12369471, compound

Procedure

1-methyl-5-nitro-2-cyanoimidazole (0.6mole) was dissolved in this mixture at 40° C. Thioacetamide (1.2 mole) was added and stirring continued for 3 hours at 40° C. The resultant solution was poured on to 4 liters of ice/water mixture and stirred for 30 minutes. The precipitate was collected, slurried with water, filtered and dried to yield 1-methyl-2-thiocarbamyl-5-nitroimidazole, m.p. 148°-50° C.

Workup

  1. stirringstirred for 30 minutes
  2. customThe precipitate was collected
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-7a3eac96a0bb45709544275ea30ca4b6
Source dataset
uspto-grants-1977_07
Patent number
US04035390

Reaction notes

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