Sodium Acetate → HCID 21425032, compound

HRID 258869Notes

Reaction equation

HRID 258869 reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]1[S:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=1.[C:17]([O-:20])(=[O:19])[CH3:18].[Na+]>CN(C)C=O>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]1[S:11][CH:12]=[C:13]([CH2:15][O:20][C:17](=[O:19])[CH3:18])[N:14]=1

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 12369474HCID 12369474, compound

Product 1

HCID 21425032HCID 21425032, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-(1-Methyl-5-nitroimidazol-2-yl)-4-chloromethylthiazole (0.7 mole) and anhydrous sodium acetate (2.5 mole) were mixed with dimethylformamide and heated for 31/2 hours. The reaction mixture was poured on to 21/2 liters of ice/water slurry and stirred. The product was collected, washed in water, dried dissolved in boiling benzene and filtered. The filtrate was evaporated to dryness to give 2-(1-methyl-5-nitroimidazol-2-yl)-4-acetoxymethylthiazole.

Workup

  1. temperatureheated for 31/2 hours
  2. customThe product was collected
  3. washwashed in water
  4. customdried
  5. dissolutiondissolved
  6. filtrationfiltered
  7. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-317caf1e92a14dc0951415f14c0fac6f
Source dataset
uspto-grants-1977_07
Patent number
US04035390

Reaction notes

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