反应详情

The aldehyde of Example 5 (192 mg., 1 mmole) in 1 ml. of water was added to a solution of ethyl cyanoacetate (125 mg., 1.1 mmole) in 1 ml. of water containing 200 mg. of sodium hydroxide. The mixture was stirred at room temperature for 20 hours then treated with 8 ml. of 2N HCl under reflux for 30 minutes. After cooling, the product was isolated by centrifugation followed by crystallization from ethanol to yield a yellow solid, m.p. 227°-228°.

1. additionthen treated with 8 ml
2. temperatureAfter cooling
3. customthe product was isolated by centrifugation
4. customfollowed by crystallization from ethanol
5. customto yield a yellow solid, m.p. 227°-228°