反应详情

77.3 Grams of decyl methylsulfonate, 44.64 grams of 1-ethoxycarbonylpiperazine, 500 ml. of ethanol, and 39 grams of potassium carbonate are combined and refluxed for approximately 44 hours under a nitrogen atmosphere. After cooling to room temperature the residue is dissolved in a mixture of water and ethyl ether. The organic layer is separated, washed three times with portions of water and dried over anhydrous sodium sulfate. The solvents are removed under reduced pressure to give 1-ethoxycarbonyl-4-decylpiperazine.

1. temperaturerefluxed for approximately 44 hours under a nitrogen atmosphere
2. customThe organic layer is separated
3. washwashed three times with portions of water
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvents are removed under reduced pressure