1-Ethylpiperazine → HCID 21423014, compound

Participants

Reaction Steps

To a stirred, refluxing solution of 0.6 gram of 3,4-dimethoxy-3-cyclobutene-1,2-dione in 20 ml. of absolute ethanol is added dropwise a solution of 1.8 grams of 1-ethylpiperazine and 20 ml. of absolute ethanol. The resulting solution is stirred overnight under a nitrogen atmosphere at room temperature. The reaction mixture is then concentrated under reduced pressure, cooled, and the resultant crystals filtered and dried to afford, as a white solid, 3,4-bis(4-ethyl-1-piperazinyl)-3-cyclobutene-1,2-dione. This compound melts at about 164°-166° C., and is represented by the following structural formula. ##STR6##

Provenance & Evidence