1-Ethylpiperazine → HCID 21423014, compound

HRID 259073Notes

Reaction equation

HRID 259073 reaction equation
CO[C:3]1[C:4](=O)[C:5](=[O:9])[C:6]=1[O:7]C.[CH2:11]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH3:12]>C(O)C>[CH2:11]([N:13]1[CH2:18][CH2:17][N:16]([C:3]2[C:6](=[O:7])[C:5](=[O:9])[C:4]=2[N:16]2[CH2:17][CH2:18][N:13]([CH2:11][CH3:12])[CH2:14][CH2:15]2)[CH2:15][CH2:14]1)[CH3:12]

Participants

4

Reactant 2

HCID 791961-EthylpiperazineHCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-

Product 1

HCID 21423014HCID 21423014, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a stirred, refluxing solution of 0.6 gram of 3,4-dimethoxy-3-cyclobutene-1,2-dione in 20 ml. of absolute ethanol is added dropwise a solution of 1.8 grams of 1-ethylpiperazine and 20 ml. of absolute ethanol. The resulting solution is stirred overnight under a nitrogen atmosphere at room temperature. The reaction mixture is then concentrated under reduced pressure, cooled, and the resultant crystals filtered and dried to afford, as a white solid, 3,4-bis(4-ethyl-1-piperazinyl)-3-cyclobutene-1,2-dione. This compound melts at about 164°-166° C., and is represented by the following structural formula. ##STR6##

Workup

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. temperaturecooled
  3. filtrationthe resultant crystals filtered
  4. customdried

Sources & evidence

ORD record
ord-f5a1b467fc744ecb85745e21b588e75f
Source dataset
uspto-grants-1977_07
Patent number
US04036828

Reaction notes

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