反应详情

A mixture of 6,7-dimethoxy-1-isochromanmethylamine hydrochloride (6.0 g), described in Example 1, and 37% formaldehyde solution (12 ml) is heated on the steam bath under a reflux condenser for 20 min. A further 6 ml formaldehyde solution is added and heating is continued for 20 min. The solution is evaporated to dryness and the residue is crystallized from isopropanol to give the hydrochloric acid addition salt of the title compound, m.p. 254°-256° C. (dec.).

1. temperatureis heated on the steam bath under a reflux condenser for 20 min
2. temperatureheating
3. customThe solution is evaporated to dryness
4. customthe residue is crystallized from isopropanol
5. customto give