Phosgene → HCID 54349766, compound

A saturated solution of phosgene is ethyl acetate (100 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer. A slurry of 5-chloromethyl-2-amino-1,3,4-thiadiazole (10 grams) in ethyl acetate (300 ml) is added to the reaction vessel, and the resulting mixture is stirred for a period of about 16 hours, resulting in the formation of a precipitate. The reaction mixture is then purged with nitrogen gas to remove unreacted phosgene. The purged mixture is then filtered to recover the desired product 5-chloromethyl-1,3,4-thiadiazol-2-yl isocyanate dimer as a solid.

1. additionis charged into a glass reaction vessel
2. customequipped with a mechanical stirrer
3. customresulting in the formation of a precipitate
4. customThe reaction mixture is then purged with nitrogen gas
5. customto remove unreacted phosgene
6. filtrationThe purged mixture is then filtered
7. customto recover the desired product 5-chloromethyl-1,3,4-thiadiazol-2-yl isocyanate dimer as a solid

ORD record

ord-c11058eca1c64caa806f54886d17ec89

Source dataset

uspto-grants-1977_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04036848