Triethylamine → HCID 20356992, compound

HRID 259237Notes

Reaction equation

HRID 259237 reaction equation
[CH2:1]1[O:10][C:9]2[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=2[O:2]1.ClC(Cl)(Cl)S(O[CH2:17][C:18]([F:21])([F:20])[F:19])(=O)=O.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:1]1[O:10][C:9]2[CH:8]=[CH:7][C:5]([NH:6][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:4][C:3]=2[O:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 843101,3-Benzodioxol-5-amineHCID 900272,2,2-Trifluoroethyl trichloromethanesulphonate

Product 1

HCID 20356992HCID 20356992, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 7 g. (0.051 mole) of 3,4-methylenedioxyaniline, 14.5 g. (0.051 mole) 2,2,2-trifluoroethyl trichloromethanesulfonate, and 5.2 g. (0.052 mole) of triethylamine in 60 ml. of toluene was heated under reflux for 31/2 hours. The cooled mixture was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The oily residue is distilled (b.p. 1.9 mm. 103°-5°) to give pure 3,4-methylenedioxy-N-(2,2,2-trifluoroethyl)aniline.

Workup

  1. additionA mixture of 7 g
  2. temperatureunder reflux for 31/2 hours
  3. washThe cooled mixture was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. distillationThe oily residue is distilled (b.p. 1.9 mm. 103°-5°)

Sources & evidence

ORD record
ord-47a557f8cb144c5ab30228af29881cad
Source dataset
uspto-grants-1977_07
Patent number
US04036962

Reaction notes

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