Hydrochloric Acid → HCID 20356988, compound

HRID 259238Notes

Reaction equation

HRID 259238 reaction equation
[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([C:6](=[O:24])[C:7]([C:19]([O:21]CC)=[O:20])=[CH:8][N:9]3[CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:4][C:3]=2[O:2]1.Cl>>[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([C:6](=[O:24])[C:7]([C:19]([OH:21])=[O:20])=[CH:8][N:9]3[CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:4][C:3]=2[O:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86734955HCID 86734955, compound

Product 1

HCID 20356988HCID 20356988, compound

Procedure

A mixture of 1 g. of the ethyl ester obtained from Example 3 and 40 ml. of 6N. hydrochloric acid was heated under reflux for 11/2 hours. The mixture was cooled and the solid product was collected by filtration and washed with water and dried under reduced pressure, m.p. 323°-5° C. (dec.).

Workup

  1. additionA mixture of 1 g
  2. temperatureunder reflux for 11/2 hours
  3. temperatureThe mixture was cooled
  4. filtrationthe solid product was collected by filtration
  5. washwashed with water
  6. customdried under reduced pressure, m.p. 323°-5° C. (dec.)

Sources & evidence

ORD record
ord-e256dc4aa1df43379ff3131c713ff48c
Source dataset
uspto-grants-1977_07
Patent number
US04036962

Reaction notes

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