反应详情

A mixture of 2- acetylbenzoic acid (6.21g), diethyl bromomalonate (9.0g.) and potassium hydroxide (2.12g.) in ethanol (50ml.) was heated under reflux for 6 hours. The cooled mixture was evaporated to dryness, water (100ml.) added and extracted with ether. The combined ethereal extracts were washed with water, dried and evaporated to dryness. The residue was heated under reflux with a mixture of concentrated hydrochloric acid (160ml.) -- acetic acid (100ml.) for two hours, cooled poured into iced water (1 liter). Filtration gave the product as a white solid, mp. 250° -2°, (lit mp. 248° -9°) (Found: C, 64.59; H, 4.01. C11H8O4 requires C, 64.70; H, 3.95).

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. customThe cooled mixture was evaporated to dryness, water (100ml.)
4. additionadded
5. extractionextracted with ether
6. washThe combined ethereal extracts were washed with water
7. customdried
8. customevaporated to dryness
9. temperatureThe residue was heated
10. temperatureunder reflux with a mixture of concentrated hydrochloric acid (160ml.)
11. temperaturecooled
12. additionpoured into iced water (1 liter)
13. filtrationFiltration