2,4-Dichlorobenzyl chloride → HCID 21424035, compound

Temperature

25 °C

To a solution of 500 mg. of 1-[2-(1-adamantyl)-2-hydroxyethyl]imidazole in 3 ml. of hexamethylphosphoramide is added 96 mg. of a 56% dispersion of sodium hydride in mineral oil. The addition of base is carried out under a nitrogen atmosphere with continuous stirring. The reaction temperature is then maintained at 25° C. for 1 hour and thereafter at 50° C. After 11/2 hours at 50° C., the reaction mixture is cooled in ice and 450 mg. α,2,4-trichlorotoluene in 3 ml. hexamethylphosphoramide is added dropwise. The temperature is then held at 5° C. for a 1 hour, then raised to 25° C. for 1 hour, and finally held at 50° C. for 2 hours. Thereafter, the resulting solution is poured into 200 ml. water. The aqueous phase is extracted with ether and the extracts washed with water, dried over magnesium sulfate and evaporated to dryness. The resulting residue is chromatographed on silica gel to effect purification. Elution with 5% acetone in dichloromethane yields 1-[2-(1-adamantyl)-2-(2,4-dichlorobenzyloxy)ethyl]imidazole which is then further characterized as the oxalate salt, decomp. 203.5°-205.5° C.

1. additionThe addition of base
2. customat 50° C
3. temperatureAfter 11/2 hours at 50° C., the reaction mixture is cooled in ice
4. temperatureraised to 25° C. for 1 hour
5. waitfinally held at 50° C. for 2 hours
6. additionThereafter, the resulting solution is poured into 200 ml
7. extractionThe aqueous phase is extracted with ether
8. washthe extracts washed with water
9. dry with materialdried over magnesium sulfate
10. customevaporated to dryness
11. customThe resulting residue is chromatographed on silica gel
12. custompurification
13. washElution with 5% acetone in dichloromethane

ORD record

ord-abcd29aec23c443f8fa94008e8d3678e

Source dataset

uspto-grants-1977_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04036975