HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-yl)acetamide | HCID 20348948 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride | HCID 20348970 | — |
Reaction Steps
The product from Example 23 (7.25 grams) is heated with 90 ml. of 1N hydrochloric acid at reflux temperature for 8.5 hours and cooled. The mixture is diluted with water and extracted with methylene chloride. The aqueous layer is then evaporated to dryness using 2-propanol for facilitating removal of water. This gives 4.85 grams of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04036979 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-9092cdb48ca747d4a844a200827c5533 |
| Source note | uspto-grants-1977_07 |