Sodium Hydroxide → 4-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one

HRID 259341Notes

Reaction equation

HRID 259341 reaction equation
Cl.[O:2]=[C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]([NH2:12])[CH2:5][CH2:4]1.[OH-].[Na+]>O>[O:2]=[C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]([NH2:12])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 233477954,5,6,7-Tetrahydro-7-oxobenzo[b]thiophen-4-amine hydrochloride

Product 1

HCID 233477964-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The free amine is obtained by neutralizing the amine hydrochloride in water with sodium hydroxide solution. It is separated by extraction with CHCl3 and removal of the CHCl3 in vacuo affords 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophen-4-amine.

Workup

  1. customIt is separated by extraction with CHCl3 and removal of the CHCl3 in vacuo

Sources & evidence

ORD record
ord-d354b11bc4894fd8a8ebc99a9b71a2f8
Source dataset
uspto-grants-1977_07
Patent number
US04036979

Reaction notes

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