Sulfuric Acid → N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea

HRID 259342Notes

Reaction equation

HRID 259342 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH2:8][CH2:9][C:2]1=2.S(=O)(=O)(O)O.[NH2:15][C:16]([NH2:18])=[O:17]>>[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]([NH:15][C:16]([NH2:18])=[O:17])[CH2:7][CH2:8][CH2:9][C:2]1=2

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 1176UreaHCID 203489656,7-Dihydrobenzo[b]thiophene

Product 1

HCID 13036998N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea

Procedure

A sample of 6,7-dihydrobenzo[b]thiophene is stirred in the cold in 96% sulfuric acid containing 4- 6 mole equivalents of urea. After 1 hour the mixture is poured on ice and the organic phase is removed. Evaporation of the organic phase to dryness in vacuo affords 4,5,6,7-tetrahydrobenzo[b]-thien-4-ylurea.

Workup

  1. additionAfter 1 hour the mixture is poured on ice
  2. customthe organic phase is removed
  3. customEvaporation of the organic phase to dryness in vacuo

Sources & evidence

ORD record
ord-32fffa2cbb6e4591925bfbcbbd25dfef
Source dataset
uspto-grants-1977_07
Patent number
US04036979

Reaction notes

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