Sodium Hydroxide → HCID 23693872, compound

HRID 259429Notes

Reaction equation

HRID 259429 reaction equation
[C:1]1([CH:7]([N:9]2[C:13]([C:14]([OH:16])=[O:15])=[CH:12][N:11]=[CH:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:18]>CC(O)C>[Na+:18].[C:1]1([CH:7]([N:9]2[C:13]([C:14]([O-:16])=[O:15])=[CH:12][N:11]=[CH:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 297427Desethyl-etomidate

Product 1

HCID 23693872HCID 23693872, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 17.7 parts of (-)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid, 3.28 parts of sodium hydroxide and 120 parts of 2-propanol is stirred and refluxed until the reaction mixture becomes homogenous and thereafter for 1 further hour. During reflux part of the product crystallizes out. The reaction mixture is allowed to cool to room temperature and the precipitated product is filtered off. The product is washed with 2-propanol and dried in vacuo, yielding (-)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid sodium salt.

Workup

  1. temperaturerefluxed until the reaction mixture
  2. temperatureDuring reflux part of the product
  3. customcrystallizes out
  4. filtrationthe precipitated product is filtered off
  5. washThe product is washed with 2-propanol
  6. customdried in vacuo

Sources & evidence

ORD record
ord-a4525b30a66345a8b9ffc15b587cb905
Source dataset
uspto-grants-1977_07
Patent number
US04038286

Reaction notes

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