2-(3-Nitrophenyl)oxazolo[4,5-b]pyridine → 3-(Oxazolo[4,5-b]pyridin-2-yl)aniline

HRID 259540Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 259540
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[O:11][C:12]3[C:13]([N:18]=2)=[N:14][CH:15]=[CH:16][CH:17]=3)[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[O:11][C:12]3[C:13]([N:18]=2)=[N:14][CH:15]=[CH:16][CH:17]=3)[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 124613742-(3-Nitrophenyl)oxazolo[4,5-b]pyridine

Produkt 1

HCID 6110863-(Oxazolo[4,5-b]pyridin-2-yl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 700mg. of 2-(3-nitrophenyl)oxazolo[4,5-b]pyridine in 50 ml. of ethanol was hydrogenated over 150 mg. of 5% palladium-on-carbon catalyst. The catalyst was removed by filtration and the solvent was concentrated to dryness. The residue was recrystallized from chloroformpetroleum ether to give 2-(3-aminophenyl)oxazolo[4,5-b]pyridine, m.p. 179°-180.5° C.

Aufarbeitung

  1. additionA mixture of 700mg
  2. customThe catalyst was removed by filtration
  3. concentrationthe solvent was concentrated to dryness
  4. customThe residue was recrystallized from chloroformpetroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-fc2a510ad2b148efac1e78dda0e36836
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04038396

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