HCID 22754786, compound → 5-Amino-2-phenyloxazolo[5,4-b]pyridine

HRID 259554Notes

Reaction equation

HRID 259554 reaction equation
[N+:1]([C:4]1[N:9]=[C:8]2[O:10][C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:12][C:7]2=[CH:6][CH:5]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[N:9]=[C:8]2[O:10][C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:12][C:7]2=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 22754786HCID 22754786, compound

Product 1

HCID 227547935-Amino-2-phenyloxazolo[5,4-b]pyridine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 361 mg. of 5-nitro-2-phenyloxazolo[ 5,4-b]pyridine in 30 ml. of methanol was hydrogenated over 0.2 g. of 5% palladium-on-carbon catalyst. The catalyst was removed by filtration, and the filtrate was concentrated to dryness. The residue was recrystallized from methanol to give 5-amino-2-phenyoxazolo[ 5,4-b]pyridine, m.p. 210° C.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated to dryness
  3. customThe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-a192dcb5f62844cb92ddd7ec0ec80b79
Source dataset
uspto-grants-1977_07
Patent number
US04038396

Reaction notes

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