Benzoyl chloride → 2-(2-Benzoylaminophenyl)oxazolo[5,4-b]pyridine

HRID 259559Notes

Reaction equation

HRID 259559 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[CH:12][N:11]=2.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>N1C=CC=CC=1>[C:17]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[CH:12][N:11]=2)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 124614212-(2-Aminophenyl)oxazolo[5,4-b]pyridine

Product 1

HCID 227547832-(2-Benzoylaminophenyl)oxazolo[5,4-b]pyridine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

An ice cold solution of 1 gram of 2-(2-aminophenyl)oxazolo[ 5,4-b]pyridine in 15 ml. of dry pyridine was treated with 1 gram of benzoyl chloride slowly. The reaction mixture was diluted with ice-water and stirred for 10 minutes and the resulting solid was collected on a filter and recrystallized from benzene to give 2-(2-benzoylaminophenyl)oxazolo[ 5,4-b]pyridine, m.p. 197°-198° C.

Workup

  1. customthe resulting solid was collected on
  2. filtrationa filter
  3. customrecrystallized from benzene

Sources & evidence

ORD record
ord-721068ad9f0041479242c01e6ab4a900
Source dataset
uspto-grants-1977_07
Patent number
US04038396

Reaction notes

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