反应详情

5-(4-Chlorobenzoyl)pentanoyl chloride (5.2g; 0.02 mole) in methylene chloride (100 ml) and ferrocene (3.75g; 0.02 mole) were stirred at 0.5° and aluminium chloride (2.7g; 0.02 mole) was added slowly over 0.5 hr. The mixture was stirred at 0.5° for 1.5 hr then water was added. The organic layer was separated. The aqueous layer was extracted with methylene chloride and the combined organic fractions were washed with water, dried (magnesium sulphate) and evaporated to yield a brown solid. This was recrystallized from petroleum ether (60°-80°) to yield pure 5-(4-chlorobenzoyl)pentanoyl ferrocene; 3.23g (40%); mp 103°-106°.

1. customThe organic layer was separated
2. extractionThe aqueous layer was extracted with methylene chloride
3. washthe combined organic fractions were washed with water
4. dry with materialdried (magnesium sulphate)
5. customevaporated
6. customto yield a brown solid
7. customThis was recrystallized from petroleum ether (60°-80°)