反应详情

2,4'-Dichloroacetophenone (0.03 mol) and 1,2,4-triazole (0.03 mol) were suspended in acetonitrile (50 ml) and cooled to -20°. Triethylamine (0.03 mol) was added dropwise with stirring. After stirring at -20° for 2 hours, the mixture was poured into water, and the product filtered off, washed with water, dried and crystallised from toluene to give pale yellow needles of 2-(1,2,4-triazol-1-yl)-4'-chloroacetophenone, m.p. 151°-3°.

1. temperaturecooled to -20°
2. stirringAfter stirring at -20° for 2 hours
3. filtrationthe product filtered off
4. washwashed with water
5. customdried
6. customcrystallised from toluene