Isopropanol → HCID 68118665, compound

HRID 259616Notes

Reaction equation

HRID 259616 reaction equation
C([NH:4][CH:5]=[CH:6][C:7]1[CH:17]=[CH:16][C:10]([O:11][CH2:12][CH:13]2[O:15][CH2:14]2)=[C:9]([O:18][CH3:19])[CH:8]=1)(=O)C.[CH:20]([NH2:23])([CH3:22])[CH3:21].[CH:24]([OH:27])(C)[CH3:25]>>[C:24]([C:5]([NH2:4])=[CH:6][C:7]1[CH:17]=[CH:16][C:10]([O:11][CH2:12][CH:13]([OH:15])[CH2:14][NH:23][CH:20]([CH3:22])[CH3:21])=[C:9]([O:18][CH3:19])[CH:8]=1)(=[O:27])[CH3:25]

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 6363IsopropylamineHCID 54180592HCID 54180592, compound

Product 1

HCID 68118665HCID 68118665, compound

Procedure

4.3 g (0.016 mol) of 1-[4-(2-acetylaminovinyl)-2-methoxy-phenoxy]-2,3-epoxy-propane are heated to 80° C. with a solution of 1.4 ml (0.016 mol) of isopropylamine in 100 ml of isopropanol for 3 hours under reflux. The mixture is then evaporated in vacuo and the curde base obtained is crystallised from isopropanol-ethyl acetate. 1-[4-(2-Acetyl-aminovinyl)-2-methoxy-phenoxy]-2-hydroxy-3-isopropylamino-propane of melting point 139°-140° C. is obtained.

Workup

  1. temperatureunder reflux
  2. customThe mixture is then evaporated in vacuo
  3. customthe curde base obtained
  4. customis crystallised from isopropanol-ethyl acetate

Sources & evidence

ORD record
ord-8a925ae32f7946a2828a60ad5968a1ef
Source dataset
uspto-grants-1977_07
Patent number
US04038414

Reaction notes

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